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Fluconazole (Diflucan) Capsules

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What is Fluconazole (Diflucan)?

Fluconazole (brand name Diflucan) is an antifungal medication primarily used to treat vaginal thrush, a yeast infection caused by an overgrowth of the Candida fungus. It also treats various other fungal infections, but less commonly. At euroClinix, it is available as Fluconazole 150 mg oral capsules.

Diflucan was first marketed by Pfizer in 1988 and has since become one of the most widely used antifungal medications across Europe due to its high rate of effectiveness and convenient single-dose treatment. When taking Diflucan for thrush, it is either taken as a single dose or, in the case of oral thrush, daily for 7-30 days.

Diflucan and Fluconazole are medically equivalent, meaning they contain the same active ingredient and produce the same effect. The main difference between them is the price, with generics generally being much cheaper, and the manufacturer.

At euroClinix, we prescribe Diflucan and its generic form, Fluconazole, specifically to treat genital thrush.

Can Fluconazole treat oral thrush?

Yes, this medication can treat both oral and genital thrush. However, the dosage required for each condition differs. Pay attention to the treatment course your doctor prescribes when starting treatment.

How does Fluconazole work?

Fluconazole works by killing the fungal cells responsible for your infection.

It does this by blocking the production of ergosterol, a key compound that protects fungal cells. Without enough ergosterol, the cell walls develop holes, causing the fungi to leak out and die. This weakens the fungal cells while leaving healthy cells unaffected.

Within 24-48 hours, symptoms like itching and irritation should be eased, and within 7 days, the infection should be completely cleared.

What are the benefits of Fluconazole?

Taking Fluconazole for thrush can offer many health benefits:

Key benefits of Fluconazole

Directly targets candida yeast Directly targets candida yeast

by targeting only the fungus, your other cells are left unaffected.

Convenient single Convenient single

dose treatment for genital thrush - no need for daily dosing.

High bioavailability High bioavailability

a high proportion (over 90%) of the drug is absorbed, reducing side effects as a lower dose is needed to be effective.

Convenient oral treatment Convenient oral treatment

negates discomfort caused by topical alternatives.

Strong formulation Strong formulation

effective against severe or persistent infections.

How effective is Fluconazole for thrush?

Clinical studies have found Fluconazole to be an effective and well-tolerated treatment for thrush.

Fluconazole vs Clotrimazole: which is better?

One study involving 150 women with vaginal thrush found Fluconazole to be more effective than Clotrimazole. Here are the key findings:

  • Complete cure - Fluconazole worked in 88% of women, compared to 72% for Clotrimazole.
  • Partial or complete cure - Fluconazole helped 92% of women, while Clotrimazole helped 72%.

This clinical data supports the efficacy of Fluconazole as a treatment for thrush.

Who can and cannot take Fluconazole?

Fluconazole tablets or capsules are versatile antifungal treatments used to treat many different infections. When you complete an online consultation with euroClinix, our doctors can determine whether this medication is safe and suitable for you.

Who can take it

This medication can be taken for the following conditions*:

  • Genital thrush
  • Oral thrush
  • Cryptococcal meningitis (a fungal infection of the brain and spinal cord)
  • Coccidioidomycosis (a fungal infection in your lungs)
  • Fungal skin and nail infections

*At euroClinix, we only prescribe Fluconazole for genital thrush. For treatment of the other conditions mentioned, visit your local GP.

Who cannot take it?

Do not take Fluconazole if you are allergic to any ingredient found in this medication.

Cautions

If any of the following apply, tell one of our doctors in your consultation:

  • You suffer from liver or kidney problems
  • You suffer from heart disease
  • You have abnormal levels of potassium, calcium, or magnesium in your blood
  • You develop severe skin reactions
  • You experience long-lasting fatigue, muscle weakness, loss of appetite, weight loss, or abdominal pain - this could be a sign of adrenal (hormone) insufficiency

Please disclose your health status during your online consultation with euroClinix. Our medical team will evaluate whether this treatment is suitable for you and may adjust your medications if needed.

How do I take Fluconazole?

To use Fluconazole tablets or capsules correctly, follow the dosage and treatment course our medical team prescribes. This ensures the drug's effectiveness and helps avoid side effects.

When taking your capsules, make sure to swallow them whole with a glass of water.

Dosage

At euroClinix, only one dose of Fluconazole is available to treat genital thrush: 150 mg. Here is some information about the usual treatment course prescribed for other conditions.

Fluconazole dosage

Genital thrush

Dosage:

One 150 mg capsule

Duration:

Single dose

Oral thrush

Dosage:

50 mg to 400 mg once daily

Duration:

7-30 days

Cryptococcal meningitis
(a fungal infection of the brain and spinal cord)

Dosage:

400 mg on the first day, then 200 mg to 400 mg once daily

Duration:

6-8 weeks (longer if needed)

Coccidioidomycosis
(a fungal disease found in mammals)

Dosage:

200 mg to 400 mg once daily

Duration:

11-24 months (longer if needed)

Internal fungal infections caused by candida yeast

Dosage:

800 mg on the first day, then 400 mg once daily

Duration:

Until you are told to stop

Other oral infections

Dosage:

200 mg to 400 mg on the first day then 100 mg to 200 mg once daily

Duration:

Until you are told to stop

Fungal skin and nail infections

Dosage:

Depends on the site of the infection

Duration:

1-4 weeks

It is important to complete the course for the entire time your doctor prescribes. Stopping treatment early can risk the infection coming back.

When do I take it?

If taking a single dose, take it when you feel most comfortable doing so.

If taking Fluconazole daily, take your capsule at the same time every day to ensure a steady flow of the active ingredient in your body throughout treatment.

How long does Fluconazole take to work?

For genital thrush or oral thrush, your infection should clear up, and symptoms should subside within 7 days.

The time Fluconazole takes to work varies from person to person. If your infection hasn’t healed within this time, consult your doctor so they can determine why and start you on a course that does.

What lifestyle changes should I make while taking Fluconazole?

While effective on its own, making some changes to your lifestyle can support treatment and increase effectiveness.

Fluconazole lifestyle tips

Maintain good hygiene Maintain good hygiene

Keep affected areas clean and dry. Use gentle, unscented cleansers and pat dry thoroughly after bathing.

Avoid irritants Avoid irritants

Stay away from scented soaps, douches, and other potential irritants that could worsen your condition.

Maintain Wear loose clothing Maintain Wear loose clothing

Wear soft, breathable fabrics and avoid tight-fitting clothes to avoid irritating the affected area and reduce moisture buildup.

Eat a balanced diet Eat a balanced diet

Maintain a healthy diet to support your immune system during treatment. Focus on nutrient-rich foods like probiotics, fruits, and vegetables.

Avoid sugar Avoid sugar

Minimize sugar intake as it can promote yeast growth. This includes refined sugars, honey, and sweetened beverages.

Iron-rich foods like spinach, lentils, and red meat (in moderation) can increase energy levels and ease side effects. Include these foods alongside a balanced diet to support your body during treatment

Silvia Fonda Nutritionist

What are the Fluconazole side effects?

Taking this medication can produce side effects.

Common side effects (may affect up to 1 in 10 people)
  • Headache
  • Stomach discomfort
  • Diarrhoea
  • Feeling sick or vomiting
  • Rash
Uncommon side effects (may affect up to 1 in 100 people)
  • Reduction in red blood cells (pale skin, weakness, breathlessness)
  • Decreased appetite
  • Trouble sleeping
  • Dizziness or a spinning sensation
  • Fits
  • Constipation or wind
  • Dry mouth
  • Muscle pain
  • Yellowing of the skin and eyes (jaundice)
  • Skin issues (hives, itching, wheals)
  • Increased sweating
  • General feeling of being unwell
Rare side effects (may affect up to 1 in 1,000 people)
  • Reduction in white blood cells
  • Red or purple discolouration of the skin
  • Raised cholesterol
  • Low blood potassium
  • Shaking
  • Changes in heart rhythm
  • Liver failure
  • Allergic reactions (blistering, rash, swelling of the lips or face)
  • Hair loss

How long do Fluconazole side effects last?

Most side effects are mild and should only last a few days, but some may persist longer. If side effects don’t go away, talk to your doctor for personalised advice.

How to manage side effects

If side effects persist or interrupt your lifestyle, consider the following:

  • Take your capsule with food - this can help relieve nausea, headache, and vomiting.
  • Stay hydrated - drink plenty of water, not just when you take your capsule, but throughout the day. This can ease headaches, dizziness, and dry mouth.
  • Rest and avoid triggers - getting enough rest can help with most side effects. Avoid caffeine and alcohol if you have trouble sleeping.
  • Maintain a balanced diet - iron-rich foods can support red blood cell production, and fibre-rich foods help prevent constipation.

Most side effects are mild and can be eased by drinking enough water and taking your capsules with food. However, if you experience jaundice, severe skin reactions, or loss of appetite, seek medical attention immediately

Dr. Caroline Fontana Lead Prescribing Doctor

For more detailed information, please refer to the patient information leaflet.

What interacts with Fluconazole?

The following medications cannot be taken with Fluconazole as they can cause dangerous heart rhythm problems:

  • Astemizole or Terfenadine (antihistamines)
  • Pimozide (Tourette’s medication)
  • Cisapride (used for stomach upsets)
  • Quinidine (used for an irregular heartbeat)
  • Erythromycin (antibiotic)

Cautions

These medications are not necessarily contraindicated, but the safety of treatment will need to be determined in your consultation if any of the following apply:

  • Warfarin (blood thinner) - can increase the risk and intensity of bleeding.
  • Alfentanil and Fentanyl (used as an anaesthetic) - can make breathing problems worse.
  • Amphotericin B, Voriconazole (antifungals) - can cause kidney damage.
  • Rifampicin, Rifabutin (antibiotics) - can make Fluconazole less effective.
  • Benzodiazepines (anti-anxiety medications) - can induce drowsiness and breathing issues.
  • Carbamazepine, Phenytoin (epilepsy medication) - increases the risk of side effects.
  • Amitriptyline, Nortriptyline (antidepressants) - can induce drowsiness, dry mouth and increase the risk to your heart.
  • Abrocitinib (eczema medication) - increases the risk of nausea, headaches, and infections.

This list does not cover all possible interactions. For a comprehensive list, please visit the interactions checker on the BNF website

What safety advice should be followed when taking Fluconazole?

Category Safety Advice
Alcohol Caution Drinking alcohol alongside Fluconazole may strain the liver and increase the risk of side effects. Exercise caution during treatment.
Pregnancy Consult your doctor This treatment can sometimes be prescribed during pregnancy, but only when other treatments have failed. Fluconazole taken during the first or second trimester of pregnancy may increase the risk of miscarriage.
Breastfeeding Consult your doctor This medication can pass into breast milk, but only in small doses. Consult your doctor before use.
Driving Caution Take care when driving or operating machinery, as this medication can induce dizziness or sickness.
Sun exposure Caution This medication can cause skin issues, like hives and itching, which can be worsened by extended exposure to the sun.

How should I store Fluconazole?

Follow these guidelines to safely store your medicine:

  • Store below 30°C in the original packaging
  • Keep away from direct heat and moisture
  • Keep this medicine out of the sight and reach of children
  • Do not use this medicine after the expiry date

Disposal

Do not throw away medicines via wastewater or household waste.

Take any unused medication to your local pharmacy for proper disposal. These measures help to protect the environment.

Can I buy Fluconazole without a prescription?

No, you cannot buy Fluconazole over the counter. This medication can only be obtained with a prescription from a licensed healthcare provider.

Prescriptions are necessary because they:

  • Ensure appropriate use for your specific condition.
  • Prevent potential misuse and associated health risks.
  • Allow for monitoring of side effects and interactions with other medications.

How do I buy Fluconazole online from euroClinix?

Ordering Fluconazole online from euroClinix is convenient.

Follow these simple steps:

  1. Complete a quick online consultation to check your eligibility.
  2. UK-registered doctors review your responses to ensure the medication is right for you.
  3. Upon approval, an e-prescription will be issued.
  4. Enjoy free delivery from our licensed pharmacy with tracking details.

Your privacy is our top priority. euroClinix uses secure, encrypted transactions and complies with UK medical standards to keep your information confidential.

Start your online consultation today to enjoy professional care from the comfort of your home.

Why should I choose euroClinix?

euroClinix is trusted by thousands of users in the UK for its safe and convenient service. Here’s why:

  • Experienced doctors manage your consultations and prescriptions.
  • Online consultations, swift approvals, and discreet doorstep delivery make ordering quick and convenient.
  • A supportive team is on hand to answer treatment-related questions or concerns.
  • Patients can manage their prescriptions hassle-free through our secure platform.

Join thousands who trust euroClinix for their healthcare needs and take control of your health today.

How much does Fluconazole cost?

The price of Fluconazole at euroClinix includes everything you need:

  • Free online consultation with our experienced doctors
  • Free prescription, if approved
  • Free delivery straight to your door

Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.

What alternatives are available?

If Fluconazole isn’t right for you, there are other treatments at euroClinix that might be better suited to your needs.

Thrush treatments compared
Choose what to compare:
Medication Form Treats Dosage Key advantages Drawbacks Price from
Fluconazole (Diflucan) Capsules Genital thrush, oral thrush Genital thrush - single dose of 150 mg
Oral thrush - 50 mg to 400 mg once daily for 7-30 days
Convenient oral treatment; available for oral and genital thrush Not suitable during pregnancy; may cause liver issues in rare cases -
Gyno-Daktarin Cream Genital thrush (vaginal only) Apply daily for 1-2 weeks Topical treatment option May cause skin irritation or burning -
Clotrimazole (Canesten) Cream (external, intravaginal), Vaginal pessaries Genital thrush Apply 2-3 times a day for 1-2 weeks Can soothe irritation fast May cause skin irritation or itching -

Fluconazole FAQs

Is Fluconazole an antibiotic?
How often can you take Fluconazole for yeast infection?
How long does Fluconazole stay in your system?
Can I use Fluconazole and a Clotrimazole pessary together?
How can I treat thrush during pregnancy?
Does Fluconazole flush out discharge?
Can Fluconazole treat ringworm?
Can men take Fluconazole?
Is it safe to buy Fluconazole online?
Will my order be confidential?
What are the delivery options available?

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 24-02-2025
Fluconazole information
Type of medicine Antifungal medication
Used for Fungal infections such as genital thrush
Active ingredient(s) Fluconazole
Works by Killing the fungus causing the infection
Effective within 7 days
Available as Capsule
Available dosage(s) 150 mg
Usage instructions Take your capsule as a single dose
Packaging Blister pack with 1 capsule
Manufacturer Pfizer
Branded available? Yes (Diflucan available as branded)
Storage Store below 30°C in its original packaging. Keep away from direct heat and moisture
Prescription required? Yes, get it with our FREE online consultation
Who is suitable for an online consultation* Adults with genital thrush

*Note: Our medical team must review your online consultation before approving this treatment. They will determine if the requested treatment and quantity are safe, appropriate, and effective for you.

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