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Spedra

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What is Spedra?

Spedra is an effective erectile dysfunction (ED) treatment. It was approved in Europe by the EMA for treatment in 2013 and has since become a popular prescription treatment for ED.

It contains the active ingredient Avanafil. It belongs to a group of medicines called PDE-5 inhibitors.

It is available in 3 doses: 50,100, and 200 mg.

How does Spedra work?

Spedra works by increasing blood flow to the penis when sexually aroused. This combats erectile dysfunction, which often stems from poor blood circulation.

Spedra is a medicine called a PDE-5 inhibitor. Here’s how Tthey work:

  • prevents an enzyme called phosphodiesterase type 5 (PDE-5) from breaking down essential molecules produced during an erection.
  • Signals the spongey tissue of the penis (the corpora cavernosa) to relax.
  • Dilates the blood vessels in the penis.

This allows blood to flow in the penis more easily, which makes achieving and maintaining an erection much easier. While it makes erections easier to achieve and maintain, Spedra does not cure ED, so you will need to take it again for future sexual encounters.

What are the benefits of Spedra?

There are several benefits of using Spedra for impotence treatment:

Benefits of Spedra
image1

Quick treatment

It takes as little as 15 minutes to start working, which is much quicker than all the other impotence treatments. This means you don’t have to wait long to enjoy the effects.

image2

Long-lasting effects

The effects of Spedra last for up to 4-5 hours, which means it allows you to be more flexible and spontaneous.

image3

Flexible dosage

It is available in 3 doses so that you can adjust if the effect is not enough or too strong.

These Spedra (Avanafil) benefits make it a convenient, flexible, and effective choice for treating erectile dysfunction.

How effective is Spedra for erectile dysfunction?

Evidence suggests that Spedra is an effective erectile dysfunction treatment in a broad range of men, including those with type 2 diabetes or post-prostate surgery, as well as men with no underlying health issues.

Here are the findings of the two Spedra clinical studies:

Spedra clinical studies

Participants:
3,400+ men

Duration:
12 weeks

Timing:
30 minutes before sexual activity


Success rate

Percentage of successful intercourse attempts

Spedra 100mg

57%

Spedra 200mg

57%

Placebo

27%

Baseline

13%

Participants:
440 men

Duration:
12 weeks

Timing:
15 minutes before sexual activity


Success rate

Percentage of successful intercourse attempts

Spedra 100mg

25%

Spedra 200mg

28%

Placebo

14%

Spedra has also been proven to be effective in men who have type 2 diabetes. One study with 390 diabetic men suffering from ED found that Spedra significantly improved erectile function, causing erections to happen within 15 minutes and lasting up to 6 hours.

These studies highlight Spedra's high success rate in treating erectile dysfunction in a wide range of individuals. In most of those who participated in the clinical studies, Spedra was found to offer rapid onset of action and reliable results.

How long does Spedra take to work?

Spedra is a fast-acting ED treatment. However, how quickly it works will vary from person to person.

Spedra works within 30 minutes with sexual stimulation. However, some evidence suggests that two-thirds of men will be able to engage in sexual activity in 15 minutes.

For that reason, it’s recommended you should wait a minimum of 15-30 minutes before sexual intercourse for Spedra to work.

Taking Spedra on an empty stomach will also ensure that the medicine works quickly, whereas factors like age, health conditions, and other medicines may make it work more slowly.

Who can use Spedra?

Spedra is suitable for most men with erectile dysfunction. However, you should always ask your doctor if you have another medical condition or take any other medication.

Who cannot use Spedra?

Do not use Spedra if you have:

  • an allergy to avanafil or any other ingredient in this medicine
  • a systolic blood pressure below 90 mmHg or above 170/100 mmHg
  • an inherited degenerative retinal disorder
  • had a heart attack
  • been told sexual activity or vasodilation is dangerous for you
  • a history of non-arteritic anterior ischaemic optic neuropathy
  • recently had a stroke
  • unstable angina

Males under 18 and women cannot take Spedra.

Cautions

Some people may need additional monitoring while using Spedra, as they may be at a higher risk of side effects.

Consult your doctor if you:

  • currently have peptic ulcers
  • are elderly
  • have a penis deformity (e.g. Peyronie’s disease)
  • have a bleeding disorder
  • have cardiovascular disease
  • are at risk of priapism (a prolonged erection)
  • are at risk of QT interval prolongation (irregular heart rhythm)

Our free consultation at euroClinix will allow our doctors to ensure that it is suitable for you to take.

How to use Spedra

To use Spedra correctly, follow the dosage and treatment course our medical team prescribes. This ensures the medication’s effectiveness, increases the chance of success, and helps avoid side effects.

What dose should I take?

Spedra is available in 3 different doses. You should take the recommended starting dose and then adjust it if needed.

50 mg 100 mg 200 mg
Starting dose if you are taking alpha-blockers or have a liver problem. Starting dose for most men. Maximum available dose.
Alternative if 100 mg is too strong. Can be increased or decreased if needed. Suitable if the 100 mg dose isn’t strong enough.

Do not take more than one tablet per day, as this can increase the risk of side effects.

If you find you need them often, you may benefit from the daily ED treatment Cialis Once Daily.

When do I take it?

You should take one tablet 15-30 minutes before sexual activity. You can take it any time of the day. But, you should avoid taking it after a big meal as this can make Spedra less effective.

How do I take it?

Swallow each tablet with a glass of water. Do not break, chew, or split tablets, as this means the medicine won’t work properly.

How long should I take it for?

Spedra has been found to be safe and effective as a long-term treatment, so long as you follow the prescribing guidelines.

Speak with your doctor about long-term use of this treatment, and only use it as-needed.

What should I do while using Spedra?

It’s also recommended you change your lifestyle habits while taking Spedra. This is because impotence is often linked to poor cardiovascular health and is linked to conditions like heart disease, high cholesterol, and high blood pressure.

To avoid side effects and boost the effectiveness of the medicine, you should try to make the following lifestyle changes.

Lifestyle guide for Spedra users

image1 Regular exercise

Improves cardiovascular health and boosts circulation. Aim for 150 minutes of moderate exercise per week if you are able.

image2 Healthy diet

Focus on lean proteins, fruits, and vegetables. Cut down on high-fat, processed, and sugary foods.

image3 Stop smoking

Smoking can double the risk of erectile dysfunction. Consider quitting to improve sexual function.

image4 Maintain a healthy weight

Reduces the risk of developing cardiovascular problems Maintain a healthy BMI for better erections.

image5 Manage stress

Stress can increase cortisol levels and lower testosterone. Practice stress-reducing techniques like meditation or yoga.

Consult with a healthcare professional before making significant lifestyle changes

What are the side effects of Spedra?

Like all prescription medicines, Spedra may cause side effects.

Common side effects

Very common and common side effects occur in 1 -10 in every 100 people using this medicine. These may include:
  • headaches
  • nasal complaints
  • Vasodilation (widening of the blood vessels)

These side effects are common as they result from blood vessels dilating. Usually, these are mild and should subside naturally.

Uncommon side effects

Uncommon side effects occur in less than 1-10 in every 100 people. These may include:
  • weakness
  • dizziness
  • drowsiness
  • difficulty breathing during exercise
  • stomach discomfort
  • muscle complaints
  • nausea
  • palpitations
  • blurred vision
  • vomiting

Rare side effects

Rare side effects occur in less than 1-10 in every 1,000 people. Rare side effects include:
  • chest pain
  • diarrhoea
  • dry mouth
  • high blood pressure
  • increased risk of infection
  • insomnia
  • gout
  • increased heart rate (tachycardia)
  • urinating more than often
  • swelling
  • itching or rash

Serious side effects

If you experience any of the following when taking Spedra, stop treatment and seek immediate medical help:

  • an erection lasting longer than 4 hours (priapism)
  • blurred vision
  • sudden vision loss in one or both eyes
  • sudden hearing loss

Any other side effects that don’t go away should be discussed with your doctor or pharmacist. For a full list of side effects, please refer to the patient information leaflet.

How to manage side effects

Taking the medicine as instructed is the best way to avoid side effects.

However, for short-term side effects, staying hydrated and taking over-the-counter painkillers are good ways to relieve discomfort.

If you find that any side effects don’t go away or get worse, see your doctor as soon as you can.

If you experience severe side effects like chest pain, you need to seek immediate medical attention.

Alcohol can intensify the side effects of Spedra, such as dizziness, headaches, and a drop in blood pressure. It is recommended to avoid or limit alcohol consumption while taking this medication to reduce the risk of these adverse effects and ensure its effectiveness.

Dr. Caroline Fontana Lead Prescribing Doctor

What interacts with Spedra?

Spedra may interact with other medicines you take.

Can increase avanafil levels:

  • medicines for HIV
  • erythromycin or clarithromycin (antibiotic)
  • ketoconazole or itraconazole (anti-fungal medicines)
  • grapefruit or grapefruit juice

Can lower avanafil levels:

  • carbamazepine or phenytoin (for epilepsy)
  • rifampicin (an antibiotic)

Can increase the risk of low blood pressure:

  • alpha-blockers (for high blood pressure or an enlarged prostate)
  • medicines to treat arrhythmias or angina
  • nitrates, medicines for angina or nitric oxide donors
  • other ED medicines and PDE-5 inhibitors

If you take any other medicines, ask your doctor before using Spedra.

For a full list of interactions, learn more here.

What safety advice should be followed when using Spedra?

Category Status Advice
Alcohol Avoid Alcohol can affect your ability to sustain and maintain erections so it can make Spedra less effective. Therefore, it’s best to avoid alcohol while using Spedra.
Lactose Caution Spedra tablets contain lactose. Do not take it if you have lactose intolerance.
Driving Caution Spedra causes side effects like dizziness and drowsiness, which may affect your ability to drive. Do not drive until you know how the medicine affects you.
Hydration Important Spedra can cause side effects like dizziness and headaches, which may worsen when dehydrated. Stay hydrated to help relieve these side effects.

How should I store Spedra?

Keep it out of sight and reach of children. You should also not use it past the expiry date. You can see the expiry date on the medicine carton after EXP. The date refers to the last day of the month.

You should take any unused or expired Spedra to a pharmacy to dispose of it. Do not dispose of it in the general waste or by flushing it down the toilet. This harms the environment.

Can I buy Spedra without a prescription?

No, Spedra is a prescription-only medication. You need a valid prescription from a healthcare professional to purchase it. This ensures the medication is safe and suitable for your needs.

You can receive an online prescription from euroClinix.

How do I buy Spedra online from euroClinix?

Ordering Spedra online from euroClinix is convenient.

Follow these simple steps:

  1. Complete a quick online consultation to check your eligibility.
  2. UK-registered doctors review your responses to ensure the medication is right for you.
  3. Upon approval, an e-prescription will be issued.
  4. Enjoy free delivery from our licensed pharmacy with tracking details.

Your privacy is our top priority. euroClinix uses secure, encrypted transactions and complies with UK medical standards to keep your information confidential.

Start your online consultation today to enjoy professional care from the comfort of your home.

Why should I choose euroClinix?

euroClinix is trusted by thousands of UK users for its safe and convenient service. Here’s why:

  • Experienced doctors manage your consultations and prescriptions.
  • Online consultations, quick approvals, and discreet doorstep delivery add to the convenience.
  • A supportive team is on hand to answer treatment-related questions or concerns.
  • Patients can manage their prescriptions hassle-free through our secure platform.

Join thousands who trust euroClinix for their healthcare needs and take control of your health today.

How much is Spedra?

The price of Spedra at euroClinix includes everything you need:

  • Free online consultation with our experienced doctors
  • Free prescription, if approved
  • Free delivery straight to your door

Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.

What are the alternatives to Spedra?

There are several treatments available similar to Spedra. While all are PDE-5 inhibitors and equally effective, they differ in how quickly they take effect.

Our ED trial pack also allows you to try each one so you can find out which treatment works best for you.

Medication Key features Time to work Effect duration Price range When to take Typical dose Efficacy Ideal for
Spedra Fastest-acting 15-30 minutes Up to 5 hours - 15-30 minutes before sex 100 mg Up to 85% effective Fast-acting treatment
Sildénafil Same as Viagra, lower price 30-60 minutes Up to 4 hours - 1 hour before sex 50 mg Up to 84% effective Reliable treatment at a lower price
Viagra Most well-known and studied 30-60 minutes Up to 4 hours - 1 hour before sex 50 mg Up to 84% effective A trustworthy and popular treatment
Cialis Longest-lasting effects, the “weekend pill” 30-60 minutes Up to 36 hours - 30-60 minutes before sex 10 mg Up to 64% effective Long-lasting treatment
Tadalafil Same as Cialis, lower price 30-60 minutes Up to 36 hours - 30-60 minutes before sex 10 mg Up to 64% effective Long-lasting treatment at a low price
Cialis Daily Taken daily, ongoing effects 3-5 days of daily use Continuous - At the same time each day 5 mg Up to 96% effective Daily dosing and ongoing effects
Vardenafil Highly tolerable for most people 30-60 minutes Up to 5 hours - 25-60 minutes before sex 10 mg Up to 80% effective Those not suited to other treatments
ED trial pack Includes Sildenafil, Tadalafil, and Vardenafil Varies per medication Varies per medication - Varies Varies Efficacy varies Exploring multiple treatment options

Spedra FAQs

Is Avanafil used for an enlarged prostate?
Is Spedra better than Viagra?
Can you take Spedra on a full stomach?
Can I take Spedra with Terbinafine?
How long does Spedra last?
Is Spedra safe?
Are there any discounts for new users?
Is it safe to buy Spedra online?
Will my order be confidential?
What are the delivery options available?

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 30-01-2025
Spedra information
Type of medicine PDE-5 inhibitor
Used for Erectile dysfunction
Active ingredient(s) Avanafil
Works by Improving blood flow to the penis
Effective within 15-30 minutes
Available as Tablets
Available dosage(s) 50, 100, and 200 mg
Usage instructions Take one tablet 30-60 minutes before sexual activity
Manufacturer Menarini International
Generic available? No
Storage Keep out of sight and reach of children
Prescription required? Yes, get it with our FREE online consultation
Who is suitable for an online consultation* Adult men with erectile dysfunction

*Note: Our medical team must review your online consultation before approving this treatment. They will determine if the requested treatment and quantity are safe, appropriate, and effective for you.

Spedra reviews
Box of 4 Spedra® 200mg Avanafil oral tablets Excellent 4.1 67 patients have reviewed Spedra on Trustpilot

Further reading

Viagra and how it reacts with other medicines

Viagra and how it reacts with other medicines

Reviewed by Dr. Caroline Fontana
Viagra: the side effects explained

Viagra: the side effects explained

Reviewed by Dr. Caroline Fontana
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