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Epiduo gel

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What is Epiduo gel?

Epiduo gel is a topical treatment used to treat acne. It contains two active ingredients that work together to fight acne blemishes (blackheads, whiteheads and inflammatory pimples), unclog pores and kill the acne bacteria.

It was approved for acne treatment in Europe by the European Medicines Agency in 2007 and is prescribed to treat mild to severe acne.

It can also be combined with oral antibiotics to treat severe acne. You can order either Lymecycline or Doxycycline as a combination pack with Epiudo gel online at euroClinix.

How does Epiduo gel work?

Epiduo gel contains two active ingredients: adapalene and benzoyl peroxide.

A graphic showing the ingredients in Epiduo gel and how they fight against acne

Adapalene is a topical retinoid. It works by speeding up the rate of skin cell reproduction. This helps to quickly remove dead skin cells and promotes the growth of new healthy skin cells.

It also helps to reduce oil production in the skin, which prevents pores from becoming clogged and therefore reduces acne blemishes.

Benzoyl peroxide is antiseptic. It targets the acne bacteria which helps treat the condition. It also helps to remove dead skin cells and softens the top layer of skin.

What are the benefits of Epiduo?

There are several benefits of using Epiduo for acne treatment:

  • Dual-action treatment - it contains two active ingredients that tackle multiple acne symptoms, which is more effective than most single-ingredient treatments.
  • Easy to use - you only have to apply it once a night before bedtime.
  • Quick results - you will start to see results in just 4 weeks, and your acne will start to fully clear by 12 weeks.

This makes Epiduo gel an effective and simple-to-use acne treatment.

How effective is Epiduo gel for acne?

Epiduo gel has been proven to treat acne vulgaris very effectively.

One study with 286 patients found:

  • 34% of people with either moderate or severe acne had either “clear” or “almost” clear skin after 12 weeks.
  • one individual who had 194 spots and blemishes prior to treatment, had just 30 blemishes after 12 weeks of treatment (an 85% reduction in symptoms).

This evidence demonstrates that Epiduo is an effective acne treatment.

How long does Epiduo take to work?

You should start to see improvements within the first 4 weeks of using it.

Although, because of how the medicine works, it’s not uncommon for your skin to appear worse before it gets better.

However, you should allow up to 12 weeks for Epiduo to clear your skin completely.

The severity of your acne, how you use the treatment and your skincare regime will impact how long it takes to work.

Who can use Epiduo?

Epiduo is suitable for most adults with mild to severe acne. However, you should always ask your doctor if you have another medical condition or take any other medication.

Epiduo is suitable for those 12 years and older who:

  • have mild to severe acne
  • have tried over-the-counter treatments without success

Who cannot use Epiduo?

Do not use Epiduo if you:

  • are allergic to Adapalene, Benzoyl peroxide or any of the inactive ingredients.
  • have severe acne that covers large areas
  • have acne on your neck
  • have sunburnt, irritated or broken skin (e.g. open wounds)

How to use Epiduo

To use Epiduo gel correctly, follow the dosage and treatment course our medical team prescribes. This ensures the medication’s effectiveness, increases the chance of success and helps avoid side effects.

When do I apply Epiduo?

You should apply Epiduo once a day. You should apply it at nighttime before you go to bed so the medicine can work overnight.

How much Epiduo should I apply?

You should apply a thin film of gel to all the affected areas. If you find that your skin is becoming irritated, it may be that you are applying too much.

How do I apply Epiduo?


Image 1 Wash your hands thoroughly before applying.
Image 2 Wash and dry the affected areas where you need to apply the gel.
Image 3 Apply a thin layer of gel to all the affected areas.
Image 3 Avoid applying gel on your eyes, lips and nostrils, as well as any broken or irritated skin.*
Image 3 Wash your hands after applying the gel, and follow up with a moisturiser.

*If you apply the gel to any of these areas, wash off immediately with soap and water.

Epiduo may also bleach fabrics. So, it’s important to wash your hands after applying the gel.

What should I do if I miss a dose?

Skip the missed dose and continue from your next regularly scheduled dose. Do not apply a double dose to make up for a missed dose. Applying too much may cause your skin to become irritated.

What should I do while using Epiduo gel?

There are some things you can do to help manage your acne and avoid side effects.

Make sure you take care of your skin whilst using Epiduo to avoid irritation. Use an SPF 50 sun cream, gentle skin care products and apply a thick moisturiser every day,

Dr. Caroline Fontana Lead Prescribing Doctor

Image 1 Avoid harsh skincare products (e.g. acids or chemical peels).
Image 2 Wash your face with a gentle cleanser before applying.
Image 3 Apply a thick moisturiser after using Epiduo.

It is also advised you use an effective method of contraception. There is a very low risk of the medicine entering the bloodstream. So, it is advised to avoid becoming pregnant as a precaution to prevent risk to an unborn baby.

What are the side effects of Epiduo gel?

Like all prescription medicines, Epiduo gel may cause side effects.

Common side effects

Very common and common side effects occur in 1 -10 in every 100 people using this medicine. These may include:

  • dry or scaling skin
  • local skin rash
  • burning sensations
  • redness

These side effects are common as this is how the medicine works, and they should subside as your skin gets used to the medicine.

Uncommon side effects

Uncommon side effects occur in less than 1-10 in every 100 people. These may include:

  • itching of the skin
  • sunburn

Rare side effects

Some side effects have been reported but are rare enough that the frequency cannot be estimated. These include:

  • allergic reactions
  • facial swelling
  • blisters
  • tightening of the skin
  • skin discolouration

For a full list of side effects, please refer to the patient information leaflet.

How to manage side effects

Skin irritation is the most common side effect of Epiduo. It is sometimes known as skin purging.

It’s normal to experience some irritation when using Epiduo. This is because the medicine speeds up the rate of skin cell turnover, meaning your skin will look worse before it gets better.

Dr. Caroline Fontana Lead Prescribing Doctor

You can change how you apply it to get your body used to treatment by:

  • alternating application days
  • applying the gel for an hour then removing it

You should also avoid sun exposure and harsh skincare products to prevent side effects.

If you experience severe irritation, you should pause or stop treatment if necessary.

What interacts with Epiduo gel?

Epiduo gel may interact with other medicines you take.

In particular, do not use Epiduo with:

  • other topical acne products
  • chemical peels
  • medicated or harsh skincare products

When used with Epiduo, they may cause additional skin irritation.

If you take any other medicines, ask your doctor before using Epiduo.

What safety advice should be followed when using Epiduo gel?

Category Status Advice
Alcohol Safe It is safe to drink alcohol whilst using Epiduo gel.
Pregnancy Avoid There is a very low risk of side effects of Epiduo during pregnancy and therefore should be avoided as a precaution.
Breastfeeding Caution The amounts of medicine transferred into milk are too small to be harmful. However, ensure the infant does not come into contact with treated areas.
Driving Safe Epiduo gel should not affect your ability to drive.
Sun exposure Avoid Epiduo can make your skin more sensitive to the sun. Sunburn can also cause irritation if Epiduo is applied. If sun exposure is unavoidable, use a SPF 50 sun cream.

How should I store Epiduo gel?

Do not store Epiduo gel above 25°C. Keep it out of sight and reach of children. Once opened, discard after 6 months.

You should also not use it past the expiry date. You can see the expiry date on the medicine carton after EXP. The date refers to the last day of the month.

You should take any unused or expired Epiduo gel to a pharmacy to be disposed of. Do not dispose of it in the general waste or by flushing it down the toilet. This harms the environment.

Can I buy Epiduo without a prescription?

No, Epiduo Gel is a prescription-only medication. You need a valid prescription from a healthcare professional to purchase it. This ensures the medication is safe and suitable for your needs.

You can receive an online prescription from euroClinix.

How do I buy Epiduo online from euroClinix?

Ordering Epiduo gel online from euroClinix is convenient.

Follow these simple steps:

  1. Complete a quick online consultation to check your eligibility.
  2. UK-registered doctors review your responses to ensure the medication is right for you.
  3. Upon approval, an e-prescription will be issued.
  4. Enjoy free delivery from our licensed pharmacy with tracking details.

Your privacy is our top priority. euroClinix uses secure, encrypted transactions and complies with UK medical standards to keep your information confidential.

Start your online consultation today to enjoy professional care from the comfort of your home.

Why should I choose euroClinix?

euroClinix is trusted by thousands of UK users for its safe and convenient service. Here’s why:

  • Experienced doctors manage your consultations and prescriptions.
  • Online consultations, quick approvals, and discreet doorstep delivery add to the convenience.
  • A supportive team is on hand to answer treatment-related questions or concerns.
  • Patients can manage their prescriptions hassle-free through our secure platform.

Join thousands who trust euroClinix for their healthcare needs and take control of your health today.

How much is Epiduo gel?

The price of Duac at euroClinix includes everything you need:

  • Free online consultation with our experienced doctors
  • Free prescription, if approved
  • Free delivery straight to your door

Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.

What are the alternatives to Epiduo?

There are many different treatments available for acne. Alternatives include creams which have a thicker consistency than gels. Some alternatives may also be combined with oral antibiotics for more severe cases of acne.

Below are some common topical acne treatment alternatives to Epiduo.

Medicine Active ingredient Suitable for Combined with oral antibiotic* Price
Epiduo gel Adapalene/ benzoyl peroxide Acne of any severity OR moderate to severe when used with an antibiotic -
Duac Once Daily Gel Benzoyl peroxide/ clindamycin phosphate Mild to moderate acne -
Differin Gel Adapalene Mild to moderate acne -
Skinoren cream Azelaic acid Mild to moderate acne OR moderate to severe when used with an antibiotic -
Treclin gel Tretinoin/ benzoyl peroxide Acne of any severity -

*Can be taken with the oral antibiotics Lymecycline or Doxycycline.

Epiduo gel FAQs

Is Epiduo gel a retinol?
Does Epiduo gel remove dark spots?
Is Epiduo gel good for acne scars?
Can I use Epiduo gel twice a day?
Do you wash off Epiduo gel?
How long should I use Epiudo gel?
Is Epiduo gel safe?
Are there any discounts for new users?
Is it safe to buy Epiduo online?
Will my order be confidential?

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 19-12-2024
Epiduo gel information
Type of medicineTopical retinoid/ antiseptic
Used forAcne
Active ingredient(s)Adapalene/ Benzoyl peroxide
Works byReducing inflammation and killing the bacteria responsible for the acne bacteria.
Effective within12 weeks
Available asGel
Available dosage(s)0.1% Adapalene/ 2.5% Benzoyl peroxide
Usage instructionsApply a thin layer once daily in the evening.
PackagingWhite plastic tube in a cardboard packaging.
ManufacturerGalderma
Generic availableNo
StorageStore below 25°C in the original packaging. Once opened, discard after 6 months.
Prescription requiredYes, get it with our FREE online consultation
Who is suitable for an online consultation*Adults with mild to severe acne
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